"The Department of Puberty" is the tenth episode of the second season of Big Mouth. It is the twentieth episode of the series overall. It premiered on October 5, 2018. It was written by Gil Ozeri and directed by Bob Suarez.
After traveling through a magic portal to Puberty Headquarters, Nick seeks out a new Hormone Monster and Jessi bonds with the Depression Kitty.
- Gavin (first appearance)
- Depression Kitty (first appearance)