A workplace comedy set in the world of the monsters from Big Mouth.
- Main article: Episode Guide
- Maurice the Hormone Monster - Maurice "Maury" The Hormone Monster is a monster that helps adolescent males through puberty. He has a stomach of steel and his favorite hobbies are getting teenage boys to masturbate, having sexual intercourse with a wall, and much more!
- Connie the Hormone Monstress - Connie is the Female ♀ hormone monster who advises girls through puberty. She shows teens that it's not so bad being a girl. If she smells good, it's just because she doesn't wear deodorant and takes nothing but bubble baths.
- The announcement of the spin-off series was made from the Big Mouth season 3 panel at New York Comic Con. It will feature the same animation style as Big Mouth.
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